George was born in Los Angeles County in Palmdale, California, and is the son of Paul George and Paulette George. He grew up with two older sisters: Teiosha, who played basketball at Pepperdine, and Portala, who played volleyball at CSU-San Bernardino. George idolized Lakers star Kobe Bryant, and he grew up rooting for the Los Angeles Lakers and Los Angeles Clippers. George spent most of his free time playing basketball at the park or one-on-one against his older sister Teiosha. He did not play organized basketball until his freshman year at Knight High School. He played for the varsity basketball team his last three years of high school under head coach Tom Hegre. George played for Pump and Run of the Amateur Athletic Union (AAU) with future UCLA Bruins Jrue Holiday and Malcolm Lee.